WYCOMBE put on a brave defensive display at Sheffield United but ultimately left empty-handed.
Wanderers boss Gary Waddock opted to play five at the back for the trip to Bramall Lane and the move frustrated the home side for large spells.
But the gulf between the two sides was made clear with Blades boss Danny Wilson able to look to his bench and turn to on-loan Brighton man Will Hoskins to make the breakthrough.
The 25-year-old needed just five minutes to break Wycombe's stubborn resistance before Ched Evans and Kevin MacDonald put the gloss on United's sixth straight home league win.
Defeat keeps Wycombe one place and one point outside the dropzone ahead of a crunch game with Yeovil at Adams Park on Valentine's Night.
The Blades enjoyed more than 75 per cent of possession in the first-half and 14 shots on goal but the scores were level at the break.
Blues goalkeeper Nikki Bull saved from Richard Cresswell and Stephen Quinn with Wycombe's best chance coming on 15 minutes when top scorer Stuart Beavon drilled a shot wide.
The home side continued to threaten, and ended the game with 23 efforts on goal and 10 on target, but the game changed when Hoskins came off the bench to fire his new side ahead on 66 minutes.
Wycombe had to change their approach and 5-4-1 formation and the Blades took advantage with Evans spinning in the box to fire in his 19 th of the season and MacDonald firing in a long-range effort in stoppage time to inflict a harsh 3-0 defeat on Wanderers.
SHEFFIELD UNITED: Simonsen, Lowton, Lescinel, Collins, Maguire, Doyle, Williamson (Flynn 46), McDonald, Quinn, Evans, Cresswell (Hoskins 61).
Subs (not used): Long, Montgomery, Porter.
WANDERERS: Bull, Foster, Laing, Winfield, Johnson (McNamee 76), Basey, Bloomfield, Harper, Whichelow (Lewis 70), Strevens (McClure 82), Beavon.
Subs (not used): McCoy, Grant.
Booked: Bloomfield (30 mins), Strevens (70 mins).